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Category: Pharmacology

Posted in: UIA > Basic Sciences > Pharmacology 2020 Language: english

Ketamine is a versatile drug with a unique profile that allows it to be successfully used for a multitude of situations worldwide. Its variable dosing means it can be used both as an induction agent with a good haemodynamic profile or in lower doses as a reliable sedative or analgesic drug. It has a vital role in prehospital and emergency medicine. As an adjunct during routine anaesthesia it can help reduce opioid requirements postoperatively. Its use in critical care includes sedation and management of refractory asthma; however, further research is required to elucidate its role in trauma and head injury patients. In the developing world, it is a vital and highly valued drug that allows performance of interventions and operations that may otherwise prove impossible, especially when resources are limited. Ketamine still suffers from traditional stigma from doctors and the public alike and it is often neglected due to concerns about psychological side effects. Increased availability of preparations of pure S-(þ)-isomer ketamine may help increase its popularity.

Posted in: E-learning > Anaesthesia & Basic Sciences > Pharmacology 2016 Language: english

Gas Man® is a unique computer tool for teaching, simulating and experimenting with anesthesia uptake and distribution. It combines an award-winning tutorial book with powerful, easy-to-use software. Each concept taught by Gas Man is fully documented and further explained in the tutorial. The Gas Man computer model graphically simulates the pharmacokinetics of anesthesia administration.

Posted in: UIA > Basic Sciences > Pharmacology 2014 Language: english

This article is intended to provide a review of the use of lidocaine as part of a balanced anaesthetic technique. Lidocaine has many properties that make it useful as an adjunct to anaesthesia. It is used routinely at the University of Virginia and other centers in the US and Europe, and we have successfully used it in the management of neurosurgical cases in Africa. In this review, we will discuss the clinical use of intraoperative intravenous lidocaine. Additionally, we will describe the method for its use and will identify potential situations where intravenous lidocaine may be of benefit to you in your anaesthetic practice.

Posted in: ATOTW > General Topics & Basic Sciences > Pharmacology 2014 Language: english

NOVEL ANTI-PLATELET AGENTS AND ANTICOAGULANTS ANAESTHESIA TUTORIAL OF THE WEEK 309 22ND SEPTEMBER 2014 Dr. Frances Smith FRCA, SpR, Peninsula Deanery Dr. Richard Telford FRCA, Consultant, Royal Devon and Exeter Hospital, UK

BLOOD COMPONENT THERAPY ANAESTHESIA TUTORIAL OF THE WEEK 262 11TH JUNE 2012 Dr Lara Herbert Dr Rob Price Royal Devon and Exeter Hospital, UK

ADJUVANT AGENTS IN NEURAXIAL BLOCKADE ANAESTHESIA TUTORIAL OF THE WEEK 230 4 th JULY 2011 Dr Nicole Khangure Registrar in Anaesthesia King Edward Memorial Hospital for Women, Western Australia

HEPARIN INDUCED THROMBOCYTOPAENIA (PART 2): MANAGEMENT ANAESTHESIA TUTORIAL OF THE WEEK 245 19TH DECEMBER 2011 Matthew Doane, Anaesthetic Specialist Registrar Gosford Hospital, NSW Australia

HEPARIN INDUCED THROMBOCYTOPENIA (PART 1) ANAESTHESIA TUTORIAL OF THE WEEK 243 5TH DECEMBER 2011 Matthew Doane, Anaesthetic Specialist Registrar Gosford Hospital, NSW Australia

Posted in: ATOTW > General Topics & Basic Sciences > Pharmacology 2011 Language: english

MICROBIOLOGY FOR ANAESTHETISTS PART 2 - ANTIBIOTIC PROHYLAXIS IN SURGERY ANAESTHESIA TUTORIAL OF THE WEEK 212 7 th FEBRUARY 2011 Dr Lesley Bromley University College London

ADRENALINE (EPINEPHRINE) ANAESTHESIA TUTORIAL OF THE WEEK 226 6 TH JUNE 2011 Prof. John Kinnear Southend University Hospital NHS Foundation Trust, UK

Posted in: ATOTW > Basic Sciences > Pharmacology 2010 Language: portuguese

Bloqueadores neuromusculares (BNMs) são utilizados em anestesia para prejudicar a transmissão neuromuscular e proporcionar relaxamento da musculatura esquelética. Essas drogas permitem ao anestesiologista realizar a intubação orotraqueal, facilitam a ventilação e promovem condições operatórias ótimas, por exemplo durante laparotomia. BNMs são compostos amônios quaternários estruturalmente semelhantes à acetilcolina (ACh) que atuam primordialmente no receptor nicotínico pós-juncional da junção neuromuscular. BNMs podem ser agonistas (BNMs “despolarizantes”) e antagonistas (BNM “adespolarizantes”) do receptor nicotínico.

CRITICAL CARE MICROBIOLOGY 2- MICROBIOLOGY CHALLENGES IN CRITICAL CARE ANAESTHESIA TUTORIAL OF THE WEEK 182 7 TH JUNE 2010 Dr.G. Lynch Rotherham General Hospital

ANTIBIOTICS IN CRITICAL CARE: AN INTRODUCTION ANAESTHESIA TUTORIAL OF THE WEEK 168 1 st FEBRUARY 2010 Dr.Shanali Thirunavakkarasu Dr.Gerry Lynch Department of Anaesthesia, Rotherham General Hospital, South Yorkshire, UK

Posted in: ATOTW > General Topics & Basic Sciences > Pharmacology 2010 Language: english

ANAESTHESIA AND PSYCHIATRIC DRUGS – PART 2 MOOD STABILISERS AND ANTIPSYCHOTICS ANAESTHESIA TUTORIAL OF THE WEEK 175 Dr Helen Bromhead, Consultant Anaesthetist Royal Hampshire County Hospital, Winchester, UK Dr Adrian Feeney, Consultant Forensic Psychiatrist Hampshire Partnership Foundation Trust, UK

Posted in: ATOTW > Basic Sciences > Pharmacology 2010 Language: english

THE ROLE OF THE LIVER IN DRUG METABOLISM ANAESTHESIA TUTORIAL OF THE WEEK 179 17th MAY 2010 Jeanne Louise Schonborn, CT2 Anaesthesia Derriford Hospital, Plymouth Carl Gwinnutt, Consultant Anaesthetist Hope Hospital, Salford

Posted in: ATOTW > General Topics & Basic Sciences > Pharmacology 2010 Language: english

MICROBIOLOGY FOR ANAESTHETISTS PART 1 - THE PHARMACOLOGY OF ANTIBACTERIAL AND ANTIVIRAL DRUGS ANAESTHESIA TUTORIAL OF THE WEEK 190 2 nd AUGUST 2010 Dr Lesley Bromley University College London

Posted in: ATOTW > General Topics & Basic Sciences > Pharmacology 2009 Language: english

ANAESTHESIA & PSYCHIATRIC DRUGS part 1 - ANTIDEPRESSANTS ANAESTHESIA TUTORIAL OF THE WEEK 164 14th DECEMBER 2009 Dr Helen Bromhead, Consultant Anaesthetist Royal Hampshire County Hospital, Winchester, UK Dr Adrian Feeney, Consultant Forensic Psychiatrist Hampshire Partnership Foundation Trust, UK

Posted in: ATOTW > Basic Sciences > Pharmacology 2009 Language: english

ANTICOAGULATION – AN OVERVIEW ANAESTHESIA TUTORIAL OF THE WEEK 143 20TH JULY 2009 Dr David Beard FRCA, SpR, South West School of Anaesthesia Dr Carl Gwinnutt FRCA, Consultant, Hope Hospital, Salford, UK

Posted in: ATOTW > General Topics & Basic Sciences > Pharmacology 2008 Language: portuguese

O QUE SÃO FÁRMACOS PARA INDUÇÃO ANESTÉSICA? São fármacos que, quando administrados por via endovenosa em dose adequada, causam rápida perda de consciência. Isso é frequentemente descrito como “um tempo braço-cérebro”, que significa o tempo necessário para que o fármaco chegue do local de injeção (geralmente o braço) até o cérebro, seu sítio de ação.

Posted in: ATOTW > General Topics & Basic Sciences > Pharmacology 2008 Language: english

INTRAVENOUS DRUGS USED FOR THE INDUCTION OF ANAESTHESIA ANAESTHESIA TUTORIAL OF THE WEEK 107 4 TH AUGUST 2008 Dr Tom Lupton, Specialist Registrar in Anaesthesia Dr Oliver Pratt, Consultant Anaesthetist Salford Royal Hospitals NHS Foundation Trust, Salford, UK

Posted in: ATOTW > General Topics & Basic Sciences > Pharmacology 2008 Language: english

MAGNESIUM AND ANAESTHESIA ANAESTHESIA TUTORIAL OF THE WEEK 90 11TH MAY 2008 Emily Shardlow, Specialist Registrar in Anaesthesia, Royal Albert Edward Infirmary, Wigan, UK

Posted in: UIA > Basic Sciences > Pharmacology 2008 Language: english

Pharmacokinetics explains what happens to a drug in the body, whereas pharmacodynamics describes the actions produced by the drug on the body. Therefore, the effects of a drug result from a combination of its pharmacokinetic and pharmacodynamic characteristics in that individual. Wherever possible, drug administration should be based on a measured patient response, which will incorporate both of these aspects of its pharmacology. However, such an approach may not always be possible.

Posted in: UIA > Basic Sciences > Pharmacology 2008 Language: english

Drugs in anaesthesia are commonly expressed in grams, milligrams or micrograms which refer to their mass.

Posted in: All > Basic Sciences > Pharmacology 2008 Language: english

Pharmacodynamics describes the processes through which a drug brings about its effect in the body. To begin to comprehend this, we must start by breaking down the interaction to a molecular level and create models to further our understanding. The fundamental principle behind a drug’s action is that to cause effect, it must interact with its target.

Posted in: UIA > Basic Sciences > Pharmacology 2008 Language: english

In 1967 pentazocine became the first opioid agonist-antagonist to be introduced into clinical practice as an analgesic. It was hoped that pentazocine would prove to be a powerful analgesic, free of the side-effects of opioid narcotics, particularly avoiding drug dependency. In practice pentazocine has proved to be less effective than hoped, but it is still used widely in resource-poor countries.

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